For years, non-specific anti-inflammatory drugs such as aspirin and paracetamol (acetaminophen) were the medications of choice for joint pain. But NSAIDs quickly became COX-2 inhibitors associated with adverse gastrointestinal effects such as peptic...
Which drugs are COX-2 inhibitors? All NSAIDs, even those not classed specifically as COX-2 inhibitors, can act to inhibit COX-2 in the body (J Rheumatol, 1998; 25: 2298-302; FASEB J, 1998; 12: 1063-73).
The COX (cyclooxygenase)-2 inhibitors, also known as ‘selective non-steroidal anti-inflammatory drugs’ (NSAIDs), have long been touted as being safer for your stomach than painkillers such as aspirin and other NSAIDs. Indeed, they were designed to...
COX-2: Still bleeding after all these years
In the heady world of the pharmaceutical industry, the most profitable industry in the world - where world sales doubled in the last five years - the pressure is always intense to develop new product.
Another anti-inflammatory bites the dust. Another COX-2 inhibitor has been shot down by the FDA. Having spent the last two months reviewing the safety of the COX-2-selective non-steroidal anti-inflammatory drugs (NSAIDs), the US regulatory agency...
DRUG ALERTS: New warnings
Vioxx (rofecoxib) is the first of a new kind of analgesic to be licensed in the UK. It employs a pioneering technology called COX-2 (selective cyclo oygenase 2 inhibitors), which is supposed to o ...
The withdrawal of a drug from the market would hardly seem grounds for Christmas cheer, but it may be simply an indication that the winds of change are finally upon us.
Rofecoxib is one of the new breed of anti-inflammatories known as COX-2 (cyclo-oxygenase-2) inhibitors that are supposed to be safer than NSAIDs such as aspirin.
What Doctors Don't Tell You