What Doctors Don't Tell YouTHE COX-2s: Oh well, back to the drawing board
The drugs industry has, for years, enjoyed a protected and privileged position that has allowed it to kill sections of its market with impunity. Sadly, those heady days seem to be coming to an end, at least in the United States.
Once upon a time there were arthritis drugs known as NSAIDs (non-steroidal anti-inflammatory drugs), but they caused gastrointestinal problems, such as ulcers.
COX-2 AGAIN: Sorry, we haven’t finished with you yet
For years, non-specific anti-inflammatory drugs such as aspirin and paracetamol (acetaminophen) were the medications of choice for joint pain. But NSAIDs quickly became COX-2 inhibitors associated with adverse gastrointestinal effects such as peptic...
Which drugs are COX-2 inhibitors? All NSAIDs, even those not classed specifically as COX-2 inhibitors, can act to inhibit COX-2 in the body (J Rheumatol, 1998; 25: 2298-302; FASEB J, 1998; 12: 1063-73).
The COX (cyclooxygenase)-2 inhibitors, also known as ‘selective non-steroidal anti-inflammatory drugs’ (NSAIDs), have long been touted as being safer for your stomach than painkillers such as aspirin and other NSAIDs. Indeed, they were designed to...
COX-2: Still bleeding after all these years
In the heady world of the pharmaceutical industry, the most profitable industry in the world - where world sales doubled in the last five years - the pressure is always intense to develop new product.
Another anti-inflammatory bites the dust. Another COX-2 inhibitor has been shot down by the FDA. Having spent the last two months reviewing the safety of the COX-2-selective non-steroidal anti-inflammatory drugs (NSAIDs), the US regulatory agency...
