HIV patients taking a combination of antiretroviral drugs may be at an increased risk of developing lipodystrophy a metabolic abnormality that can result in weight gain and fat redistribution. ...
Protease inhibitors considered the great hope for HIV treatment cause strange fatty deposits in patients, some so severe that "buffalo humps" along the spine have been reported. ...
Several years ago, protease inhibitors were the Great White Hope of AIDS therapy. These drugs work by inhibiting the enzyme protease, which is crucial to HIV’s ability to reproduce.