Vaccine: A Holistic Approach to a Common Medical Procedure

The most commonly performed medical procedure for pet cats is annual immunization. For many years this has been a standard practice and recommendation. Over the last few years, new information has come to light that has caused us to question the validity of this recommendation. Research has shown that most cats can mount an immune response to vaccination that lasts longer than 12 months; in some instances vaccines have produced immunity lasting many years. As a result, many veterinarians have recommended vaccinating cats every 3 years rather than annually. But is this recommendation the best one? Is it possible that a better vaccine protocol would be more suitable for your cat? Does every cat even need any vaccines? This article will explore the topic of immunization and present a holistic alternative that has worked well in my practice.

While the recommendation for annual immunization has been the standard of practice for many years, there is really no scientific basis for it. Because there are potential short term and long term complications with vaccinations (see box,) and because it’s not good medical practice to do something that is of no real value and potential harm to our patients, researchers have investigated the value of increasing the time interval between vaccinations. Current recommendations are for most cats to be immunized every 3 years, although individual recommendations will vary based upon many factors (indoor versus outdoor cat, young cat versus older cat, etc.) While vaccinating every 3 years is preferable to vaccinating every year, I believe it’s better to try and determine what’s best for each individual cat rather than accepting a blanket recommendation for all of my feline patients. Therefore, in my practice I prefer the use of antibody (vaccine) titers to determine the need for vaccination.

These simple blood tests can give us information about an individual pet’s antibody status in relation to specific diseases. In simple terms, antibodies are proteins made by the pet’s white blood cells (specifically B lymphocytes.) These antibodies are made whenever a pet contacts an infectious organism (virus or bacteria, as a result of a natural infection) or is vaccinated (the vaccine uses low doses of infectious organisms, tricking the immune system to form protective antibodies without causing disease as might occur in a natural infection.) Using a titer test reveals each pet’s antibody status. These results are then interpreted in an attempt to determine if the pet is currently protected against a specific infectious disease or if the pet may require immunization.

There are both pros and cons to the use of vaccine (antibody) titers to determine the need to immunize pets.


  1. Easy to perform.

  2. Inexpensive (usually under $50.)

  3. Gives us specific information about each individual patient, allowing the doctor and owner to make a rational and informed decision.

  4. Replaces the current recommendation for vaccinating every pet regardless of actual need every 1-3 years.


  1. While inexpensive, the extra cost may prohibit some owners from taking advantage of the testing.

  2. Some diseases will not be titered; rather, automatic immunization will still be given. This is the case for the rabies vaccine, which must be given following state law.

  3. Not all diseases produce a measurable titer. (For example, antibody levels have been shown to correlate with protection against feline panleukopenia virus but not with feline enteric coronavirus or feline chlamydial infection. Cellular immunity (rather than antibodies) provides protection against feline rhinotracheitis virus and feline infectious peritonitis virus, making titers inaccurate in interpreting protection for these diseases.) There is still adequate protection due to the cellular immunity the vaccines for these diseases produce.

  4. Titers, like vaccines, are not perfect. There is no guarantee that a pet with an adequate titer (or an annual vaccination) will not become infected or become ill with a disease. The titer only tells us that the pet should have adequate antibodies to fight off the infectious organism and that the pet possesses the ability to mount a secondary antibody response (and fight off the disease.)

  5. There is no agreed upon correct titer level for determining protective titers. Currently, doctors must use all of the conflicting information available and make an educated decision regarding what constitutes an “adequate, protective” titer. For feline panleukopenia, one suggested protective titer is >1:40, and this can be used as a rough guideline. (Currently, the use of titers is not perfect but gives us some information about each individual pet. Most holistic doctors will consider immunization if the pet fails to detect a titer of anywhere from >1:5, although some will use the upper end of the titers as mentioned above. The presence of any titer for those diseases in which titer information correlates with disease protection indicates the ability of the pet to respond to immunization and possibly infection. More research is needed to determine which vaccines induce the longest lasting protection, and how titer levels correlate with these specific vaccines.)

In summary, I believe the best recommendations for determining how to handle the “vaccination controversy) at this point are as follows:

  • While not perfect, titers are the only inexpensive way to assess each pet’s unique vaccine needs.
  • Standardized testing should be adopted, along with an agreed upon “correct” level to constitute a protective titer (this may be difficult, as each vaccine manufacturer would need to determine the “correct” level for each vaccine produced.)
  • Any titer indicates the ability of the pet to respond to immunization. The higher the titer, the greater the antibody level at the time of the testing. As long as the pet has protective immunity, however, vaccines are not needed as they do not “boost” the immune system.
  • Until we have more information, we probably need to use published studies by vaccine manufacturers showing the levels of titers that afforded vaccinated puppies and kittens protection from disease challenge.

    At this time, most holistic veterinarians use a combination of blood titers plus their knowledge of the pet’s lifestyle. For example, an outdoor cat is at higher risk of coming in contact with cats that may transmit infectious diseases. The need for this cat to be adequately immunized is greater than the cat that never leaves the house except to go for a veterinary visit 1-2 times each year and has little chance of ever contracting an infectious disease. In order to maximize your cat’s ability to withstand infection and disease, a strong immune system (maintained by a healthy diet supplemented with quality nutritional supplements) is of paramount importance.

    Pets with chronic immune disorders (cancer, allergies, epilepsy, kidney disease, heart disease, liver disease, thyroid disease, etc.) may be at increased risk for further immune damage from the unnecessary use of chemicals such as flea products, preservatives in most commercial pet foods, and vaccines. While controversial, most holistic doctors, including myself, recommend never administering vaccines to pets with any chronic, serious disorder, especially those involving the immune system. Pets with mild problems (such as well controlled allergies) can probably be vaccinated safely if their allergies are under control and titer testing indicates a need for vaccination. This is an individual decision as many disorders seem to appear shortly after immunization, and chronic disorders may be exacerbated (more itching in allergic pets, more seizures in an epileptic pet, etc.) following immunization. While rare, pets in remission following a diagnosis of cancer have been known to relapse following immunization; as a rule, most doctors do not recommend ever revaccinating pets with cancer. Pets undergoing stress (illness) should not be immunized. Cats who have experienced vaccine reactions, as well as those whose closely-related family members have a documented clinical illness following immunization should probably not be over-vaccinated, and possibly not vaccinated at all.
    The following recommendations seem prudent for pets that must receive vaccinations (extrapolated from Rivera P. Vaccinations and Vaccinosis, Journal AHVMA, Feb-Apr 1997, Vol 16, No 1:19-24.)

    1. Only immunize healthy pets.
    2. Shedding of viral particles can occur in the feces of pets vaccinated with modified-live viruses. These pets should not be exposed to sick pets or unvaccinated pets for at least 2-3 weeks following immunization.
    3. Consider the animal’s lifestyle when deciding when to immunize and which vaccines to immunize (what diseases is the pet most likely to encounter considering its lifestyle.)
    4. Don’t let vaccines substitute for proper medical care (good diet, supplements, prevention of disease via regular dental cleanings and necessary laboratory testing.)
    5. Don’t vaccinate pregnant animals.
    6. Don’t vaccinate animals during their estrus (heat) cycles.
      While controversial, there is a definite need to minimize immunizations in pets (and I also believe in people, particularly children.) Using vaccine titers as part of a health maintenance program will help achieve this goal and keep your pet healthy.

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    Written by Shawn Messonnier DVM

    Explore Wellness in 2021