New uppers: no improvement

The SSRI group of antidepressants – including fluoxetine and paroxetine – are no more effective and have no fewer side effects than the older tricyclic antidepressants, according to an overview of six double-blind studies (Curr Ther Res, 1993; 54).

This latest finding adds weight to an earlier paper (BMJ, 1993; 306: 683-7) which contradicted previous claims that SSRIs – selective serotonin reuptake inhibitors (also known as 5-HT-blockers) – had considerable benefits over old-style antidepressants, including fewer side effects. The latest finding suggests that the severity of side effects from SSRIs may be greater than with tricyclic antidepressants.

‘Premature withdrawal from treatment due to adverse events was more frequent with SSRIs than with dothiepin (15.5 per cent compared with 5.6 per cent),’ the report concluded.

What Doctors Don't Tell You Written by What Doctors Don't Tell You

We Humbly Recommend

Get the Healthiest Newsletter!

Get a dose of Healthy delivered straight to your inbox. Each FREE issue features amazing content that will elevate your Body, Mind, and Spirit.

Your data is never shared with 3rd parties


Healthy Shopping

Health and Wellbeing products lovingly curated for you.